Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness

Tonic signaling of chimeric antigen receptor (CAR), i.e., the spontaneous CAR activation in the absence of tumor antigen stimulation, is considered to be a pivotal event controlling CAR-T efficacy. However, the molecular mechanism underlying the spontaneous CAR signals remains elusive. Here, we unve...

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Detalles Bibliográficos
Autores principales: Chen, Jian, Qiu, Shizhen, Li, Wentao, Wang, Kun, Zhang, Yu, Yang, Han, Liu, Baichuan, Li, Guangfei, Li, Li, Chen, Min, Lan, Junjie, Niu, Jiahua, He, Peijie, Cheng, Lei, Fan, Gaofeng, Liu, Xin, Song, Xianmin, Xu, Chenqi, Wu, Haitao, Wang, Haopeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156745/
https://www.ncbi.nlm.nih.gov/pubmed/36882513
http://dx.doi.org/10.1038/s41422-023-00789-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156745/
https://www.ncbi.nlm.nih.gov/pubmed/36882513
http://dx.doi.org/10.1038/s41422-023-00789-0

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