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Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness
Tonic signaling of chimeric antigen receptor (CAR), i.e., the spontaneous CAR activation in the absence of tumor antigen stimulation, is considered to be a pivotal event controlling CAR-T efficacy. However, the molecular mechanism underlying the spontaneous CAR signals remains elusive. Here, we unve...
Autores principales: | Chen, Jian, Qiu, Shizhen, Li, Wentao, Wang, Kun, Zhang, Yu, Yang, Han, Liu, Baichuan, Li, Guangfei, Li, Li, Chen, Min, Lan, Junjie, Niu, Jiahua, He, Peijie, Cheng, Lei, Fan, Gaofeng, Liu, Xin, Song, Xianmin, Xu, Chenqi, Wu, Haitao, Wang, Haopeng |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Nature Singapore
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156745/ https://www.ncbi.nlm.nih.gov/pubmed/36882513 http://dx.doi.org/10.1038/s41422-023-00789-0 |
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