Organoid models of fibrolamellar carcinoma mutations reveal hepatocyte transdifferentiation through cooperative BAP1 and PRKAR2A loss

Fibrolamellar carcinoma (FLC) is a lethal primary liver cancer, affecting young patients in absence of chronic liver disease. Molecular understanding of FLC tumorigenesis is limited, partly due to the scarcity of experimental models. Here, we CRISPR-engineer human hepatocyte organoids to recreate di...

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Detalles Bibliográficos
Autores principales: Rüland, Laura, Andreatta, Francesco, Massalini, Simone, Chuva de Sousa Lopes, Susana, Clevers, Hans, Hendriks, Delilah, Artegiani, Benedetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156813/
https://www.ncbi.nlm.nih.gov/pubmed/37137901
http://dx.doi.org/10.1038/s41467-023-37951-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156813/
https://www.ncbi.nlm.nih.gov/pubmed/37137901
http://dx.doi.org/10.1038/s41467-023-37951-6

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