Unveiling an indole alkaloid diketopiperazine biosynthetic pathway that features a unique stereoisomerase and multifunctional methyltransferase

The 2,5-diketopiperazines are a prominent class of bioactive molecules. The nocardioazines are actinomycete natural products that feature a pyrroloindoline diketopiperazine scaffold composed of two D-tryptophan residues functionalized by N- and C-methylation, prenylation, and diannulation. Here we i...

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Detalles Bibliográficos
Autores principales: Deletti, Garrett, Green, Sajan D., Weber, Caleb, Patterson, Kristen N., Joshi, Swapnil S., Khopade, Tushar M., Coban, Mathew, Veek-Wilson, James, Caulfield, Thomas R., Viswanathan, Rajesh, Lane, Amy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156859/
https://www.ncbi.nlm.nih.gov/pubmed/37137876
http://dx.doi.org/10.1038/s41467-023-38168-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156859/
https://www.ncbi.nlm.nih.gov/pubmed/37137876
http://dx.doi.org/10.1038/s41467-023-38168-3

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