IP6‐stabilised HIV capsids evade cGAS/STING‐mediated host immune sensing

HIV‐1 uses inositol hexakisphosphate (IP6) to build a metastable capsid capable of delivering its genome into the host nucleus. Here, we show that viruses that are unable to package IP6 lack capsid protection and are detected by innate immunity, resulting in the activation of an antiviral state that...

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Detalles Bibliográficos
Autores principales: Papa, Guido, Albecka, Anna, Mallery, Donna, Vaysburd, Marina, Renner, Nadine, James, Leo C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157305/
https://www.ncbi.nlm.nih.gov/pubmed/36970882
http://dx.doi.org/10.15252/embr.202256275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157305/
https://www.ncbi.nlm.nih.gov/pubmed/36970882
http://dx.doi.org/10.15252/embr.202256275

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