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IP6‐stabilised HIV capsids evade cGAS/STING‐mediated host immune sensing
HIV‐1 uses inositol hexakisphosphate (IP6) to build a metastable capsid capable of delivering its genome into the host nucleus. Here, we show that viruses that are unable to package IP6 lack capsid protection and are detected by innate immunity, resulting in the activation of an antiviral state that...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157305/ https://www.ncbi.nlm.nih.gov/pubmed/36970882 http://dx.doi.org/10.15252/embr.202256275 |