Preclinical Evaluation of ON203, A Novel Bioengineered mAb Targeting Oxidized Macrophage Migration Inhibitory Factor as an Anticancer Therapeutic

High levels of macrophage migration inhibitory factor (MIF) in patients with cancer are associated with poor prognosis. Its redox-dependent conformational isoform, termed oxidized MIF (oxMIF), is a promising tumor target due to its selective occurrence in tumor lesions and at inflammatory sites. A f...

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Detalles Bibliográficos
Autores principales: Rossmueller, Gregor, Mirkina, Irina, Maurer, Barbara, Hoeld, Verena, Mayer, Julia, Thiele, Michael, Kerschbaumer, Randolf J., Schinagl, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
MCT First Disclosures
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157364/
https://www.ncbi.nlm.nih.gov/pubmed/37067909
http://dx.doi.org/10.1158/1535-7163.MCT-22-0676

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157364/
https://www.ncbi.nlm.nih.gov/pubmed/37067909
http://dx.doi.org/10.1158/1535-7163.MCT-22-0676

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