DNA demethylation fine‐tunes IL‐2 production during thymic regulatory T cell differentiation

Regulatory T (T reg) cells developing in the thymus are essential to maintain tolerance and prevent fatal autoimmunity in mice and humans. Expression of the T reg lineage‐defining transcription factor FoxP3 is critically dependent upon T cell receptor (TCR) and interleukin‐2 (IL‐2) signaling. Here,...

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Detalles Bibliográficos
Autores principales: Teghanemt, Athmane, Misel‐Wuchter, Kara, Heath, Jace, Thurman, Andrew, Pulipati, Priyanjali, Dixit, Garima, Geesala, Ramasatya, Meyerholz, David K, Maretzky, Thorsten, Pezzulo, Alejandro, Issuree, Priya D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157375/
https://www.ncbi.nlm.nih.gov/pubmed/36880575
http://dx.doi.org/10.15252/embr.202255543

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157375/
https://www.ncbi.nlm.nih.gov/pubmed/36880575
http://dx.doi.org/10.15252/embr.202255543

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