Development of Hyphenated Techniques and Network Identification Approaches for Biotransformational Evaluation of Promising Antitubercular N-pyrrolyl hydrazide-hydrazone in Isolated Rat Hepatocytes

Novel, rapid and precise RP-HPLC–DAD method was developed, validated and successfully applied for determination of metabolic changes of ethyl 5-(4-bromophenyl)-1-(3-(2-(2-hydroxybenzylidene)hydrazinyl)-3-oxopropyl)-2-methyl-1H-pyrrole-3-carboxylate (12b) in isolated rat hepatocytes. The analytes wer...

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Detalles Bibliográficos
Autores principales: Mateeva, Alexandrina, Kondeva-Burdina, Magdalena, Nedialkov, Paraskev, Peikova, Lily, Georgieva, Maya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Original
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157554/
https://www.ncbi.nlm.nih.gov/pubmed/37255951
http://dx.doi.org/10.1007/s10337-023-04260-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157554/
https://www.ncbi.nlm.nih.gov/pubmed/37255951
http://dx.doi.org/10.1007/s10337-023-04260-5

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