Methionine-Containing Peptides: Avoiding Secondary Reactions in the Final Global Deprotection

[Image: see text] The solid-phase synthesis of Met-containing peptides using a fluorenylmethoxycarbonyl (Fmoc)/tert-butyl (tBu) protection scheme is inevitably accompanied by two stubborn side reactions, namely, oxidation and S-alkylation (tert-butylation), which result in the formation of Met(O) an...

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Detalles Bibliográficos
Autores principales: Nandhini, K. P., Alhassan, Mahama, Veale, Clinton G. L., Albericio, Fernando, de la Torre, Beatriz G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157837/
https://www.ncbi.nlm.nih.gov/pubmed/37151509
http://dx.doi.org/10.1021/acsomega.3c01058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157837/
https://www.ncbi.nlm.nih.gov/pubmed/37151509
http://dx.doi.org/10.1021/acsomega.3c01058

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