KLF4-mediated upregulation of the NKG2D ligand MICA in acute myeloid leukemia: a novel therapeutic target identified by enChIP

The immunoreceptor NKG2D, which is expressed on NK cells and T cell subsets is critically involved in tumor immune surveillance. This applies in particular to acute myeloid leukemia (AML), which evades immune detection by downregulation of NKG2D ligands (NKG2D-L), including MICA. The absence of NKG2...

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Detalles Bibliográficos
Autores principales: Alkhayer, Reem, Ponath, Viviane, Frech, Miriam, Adhikary, Till, Graumann, Johannes, Neubauer, Andreas, von Strandmann, Elke Pogge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157933/
https://www.ncbi.nlm.nih.gov/pubmed/37143070
http://dx.doi.org/10.1186/s12964-023-01118-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157933/
https://www.ncbi.nlm.nih.gov/pubmed/37143070
http://dx.doi.org/10.1186/s12964-023-01118-z

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