Sequential treatment with a TNFR2 agonist and a TNFR1 antagonist improves outcomes in a humanized mouse model for MS

TNF signaling is an essential regulator of cellular homeostasis. Through its two receptors TNFR1 and TNFR2, soluble versus membrane-bound TNF enable cell death or survival in a variety of cell types. TNF-TNFRs signaling orchestrates important biological functions such as inflammation, neuronal activ...

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Detalles Bibliográficos
Autores principales: Pegoretti, Valentina, Bauer, Jan, Fischer, Roman, Paro, Iskra, Douwenga, Wanda, Kontermann, Roland E., Pfizenmaier, Klaus, Houben, Evelien, Broux, Bieke, Hellings, Niels, Baron, Wia, Laman, Jon D., Eisel, Ulrich L. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157968/
https://www.ncbi.nlm.nih.gov/pubmed/37138340
http://dx.doi.org/10.1186/s12974-023-02785-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157968/
https://www.ncbi.nlm.nih.gov/pubmed/37138340
http://dx.doi.org/10.1186/s12974-023-02785-y

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