Bulk and single-cell transcriptome profiling reveal extracellular matrix mechanical regulation of lipid metabolism reprograming through YAP/TEAD4/ACADL axis in hepatocellular carcinoma

Emerging studies have revealed matrix stiffness promotes hepatocellular carcinoma (HCC) development. We studied metabolic dysregulation in HCC using the TCGA-LIHC database (n=374) and GEO datasets (GSE14520). HCC samples were classified into three heterogeneous metabolic pathway subtypes with differ...

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Detalles Bibliográficos
Autores principales: Cai, Jingwei, Chen, Tianyi, Jiang, Zhiyu, Yan, Jiafei, Ye, Zhengtao, Ruan, Yeling, Tao, Liye, Shen, Zefeng, Liang, Xiao, Wang, Yifan, Xu, Junjie, Cai, Xiujun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158031/
https://www.ncbi.nlm.nih.gov/pubmed/37151879
http://dx.doi.org/10.7150/ijbs.82177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158031/
https://www.ncbi.nlm.nih.gov/pubmed/37151879
http://dx.doi.org/10.7150/ijbs.82177

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