Kinetic analysis of RNA cleavage by coronavirus Nsp15 endonuclease: Evidence for acid–base catalysis and substrate-dependent metal ion activation

Understanding the functional properties of severe acute respiratory syndrome coronavirus 2 nonstructural proteins is essential for defining their roles in the viral life cycle, developing improved therapeutics and diagnostics, and countering future variants. Coronavirus nonstructural protein Nsp15 i...

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Detalles Bibliográficos
Autores principales: Huang, Tong, Snell, Kimberly C., Kalia, Nidhi, Gardezi, Shahbaz, Guo, Lily, Harris, Michael E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158045/
https://www.ncbi.nlm.nih.gov/pubmed/37149147
http://dx.doi.org/10.1016/j.jbc.2023.104787

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158045/
https://www.ncbi.nlm.nih.gov/pubmed/37149147
http://dx.doi.org/10.1016/j.jbc.2023.104787

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