mTOR-dependent TFEB activation and TFEB overexpression enhance autophagy-lysosome pathway and ameliorate Alzheimer's disease-like pathology in diabetic encephalopathy

BACKGROUND: Diabetic encephalopathy (DE) is a complication of type 2 diabetes mellitus (T2DM) that features Alzheimer's disease (AD)-like pathology, which can be degraded by the autophagy-lysosome pathway (ALP). Since transcription factor EB (TFEB) is a master regulator of ALP, TFEB-mediated AL...

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Detalles Bibliográficos
Autores principales: Cheng, Lizhen, Chen, Yixin, Guo, Donghao, Zhong, Yuan, Li, Wei, Lin, Yijia, Miao, Ya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158341/
https://www.ncbi.nlm.nih.gov/pubmed/37143104
http://dx.doi.org/10.1186/s12964-023-01097-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158341/
https://www.ncbi.nlm.nih.gov/pubmed/37143104
http://dx.doi.org/10.1186/s12964-023-01097-1

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