Intestinal barrier dysfunction in murine sickle cell disease is associated with small intestine neutrophilic inflammation, oxidative stress, and dysbiosis

The intestinal microbiome has emerged as a potential contributor to the severity of sickle cell disease (SCD). We sought to determine whether SCD mice exhibit intestinal barrier dysfunction, inflammation, and dysbiosis. Using the Townes humanized sickle cell mouse model, we found a 3‐fold increase i...

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Detalles Bibliográficos
Autores principales: Lewis, Caitlin V., Sellak, Hassan, Sawan, Mariem A., Joseph, Giji, Darby, Trevor M., VanInsberghe, David, Naudin, Crystal R., Archer, David R., Jones, Rheinallt M., Taylor, W. Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158626/
https://www.ncbi.nlm.nih.gov/pubmed/37151850
http://dx.doi.org/10.1096/fba.2022-00121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158626/
https://www.ncbi.nlm.nih.gov/pubmed/37151850
http://dx.doi.org/10.1096/fba.2022-00121

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