Cargando…

Impaired bone strength and bone microstructure in a novel early-onset osteoporotic rat model with a clinically relevant PLS3 mutation

Plastin 3 (PLS3), a protein involved in formation of filamentous actin (F-actin) bundles, is important in human bone health. Recent studies identify PLS3 as a novel bone regulator and PLS3 mutations can lead to a rare monogenic early-onset osteoporosis. However, the mechanism of PLS3 mutation leadin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Jing, Zhou, Bingna, Lin, Xiaoyun, Zhang, Qian, Guan, Feifei, Sun, Lei, Liu, Jiayi, Wang, Ou, Jiang, Yan, Xia, Wei-bo, Xing, Xiaoping, Li, Mei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2023
Materias:	Genetics and Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10159618/ https://www.ncbi.nlm.nih.gov/pubmed/37083757 http://dx.doi.org/10.7554/eLife.80365

Ejemplares similares

Contrasting effects of Ksr2, an obesity gene, on trabecular bone volume and bone marrow adiposity
por: Gomez, Gustavo A, et al.
Publicado: (2022)

Study on the association of the microstructure and bone metabolism in the osteoporotic femoral head
por: Wang, Cheng, et al.
Publicado: (2023)

Genetic parameters for bone ash and phosphorus utilization in an F(2) cross of Japanese quail
por: Künzel, Susanne, et al.
Publicado: (2019)

The intricate mechanism of PLS3 in bone homeostasis and disease
por: Zhong, Wenchao, et al.
Publicado: (2023)

Interaction between the bone morphogenetic proteins and Ras/MAP-kinase signalling pathways in lung cancer
por: Kraunz, K S, et al.
Publicado: (2005)

WNT16 Influences Bone Mineral Density, Cortical Bone Thickness, Bone Strength, and Osteoporotic Fracture Risk
por: Zheng, Hou-Feng, et al.
Publicado: (2012)

R-spondin 3 deletion induces Erk phosphorylation to enhance Wnt signaling and promote bone formation in the appendicular skeleton
por: Nagano, Kenichi, et al.
Publicado: (2022)

The relevance of gene flow with wild relatives in understanding the domestication process
por: Moreno-Letelier, Alejandra, et al.
Publicado: (2020)

Functional and prognostic relevance of the homeobox protein MSX2 in malignant melanoma
por: Gremel, G, et al.
Publicado: (2011)

Relevance of BCAR4 in tamoxifen resistance and tumour aggressiveness of human breast cancer
por: Godinho, M F E, et al.
Publicado: (2010)

Gene expression profiling identifies distinct molecular subgroups of leiomyosarcoma with clinical relevance
por: Lee, Yin-Fai, et al.
Publicado: (2016)

Functional genetic diversity in an exploited marine species and its relevance to fisheries management
por: Petrou, Eleni L., et al.
Publicado: (2021)

Comparative transcriptomic analysis reveals translationally relevant processes in mouse models of malaria
por: Georgiadou, Athina, et al.
Publicado: (2022)

Bionic Tiger‐Bone Powder Improves Bone Microstructure and Bone Biomechanical Strength of Ovariectomized Rats
por: Ren, Shanwu, et al.
Publicado: (2021)

HER2 status of bone marrow micrometastasis and their corresponding primary tumours in a pilot study of 27 cases: a possible tool for anti-HER2 therapy management?
por: Vincent-Salomon, A, et al.
Publicado: (2007)

Rare germline mutations in the BRCA2 gene are associated with early-onset prostate cancer
por: Agalliu, I, et al.
Publicado: (2007)

HPC2/ELAC2 polymorphisms and prostate cancer risk: analysis by age of onset of disease
por: Meitz, J C, et al.
Publicado: (2002)

MSH6 germline mutations in early-onset colorectal cancer patients without family history of the disease
por: Pinto, C, et al.
Publicado: (2006)

Effect of different cytokines on mammaglobin and maspin gene expression in normal leukocytes: possible relevance to the assays for the detection of micrometastatic breast cancer
por: Ballestrero, A, et al.
Publicado: (2005)

Development of a gene panel for next-generation sequencing of clinically relevant mutations in cell-free DNA from cancer patients
por: Malapelle, Umberto, et al.
Publicado: (2017)

Sequencing of DICER1 in sarcomas identifies biallelic somatic DICER1 mutations in an adult-onset embryonal rhabdomyosarcoma
por: de Kock, Leanne, et al.
Publicado: (2017)

Impairment of MLH1 and CDKN2A in oncogenesis of laryngeal cancer
por: Sasiadek, M M, et al.
Publicado: (2004)

Effects of symbiotic population impairment on microbiome composition and longevity of Bactrocera dorsalis
por: Akami, Mazarin, et al.
Publicado: (2021)

Effect of testosterone, raloxifene and estrogen replacement on the microstructure and biomechanics of metaphyseal osteoporotic bones in orchiectomized male rats
por: Stuermer, E. K., et al.
Publicado: (2009)

BRCA2 is a moderate penetrance gene contributing to young-onset prostate cancer: implications for genetic testing in prostate cancer patients
por: Kote-Jarai, Z, et al.
Publicado: (2011)

Targeting subchondral bone in osteoporotic osteoarthritis
por: Roman-Blas, Jorge A, et al.
Publicado: (2014)

Advances in Osteoporotic Bone Tissue Engineering
por: Codrea, Cosmin Iulian, et al.
Publicado: (2021)

Bone Mass and Strength in Older Men With Type 2 Diabetes: The Osteoporotic Fractures in Men Study
por: Petit, Moira A, et al.
Publicado: (2010)

Comparison of the Pullout Strength of Different Pedicle Screw Designs and Augmentation Techniques in an Osteoporotic Bone Model
por: Kiyak, Gorkem, et al.
Publicado: (2018)

Reprogramming of translation in yeast cells impaired for ribosome recycling favors short, efficiently translated mRNAs
por: Gaikwad, Swati, et al.
Publicado: (2021)

Variation in the fibroblast growth factor 23 (FGF23) gene associates with serum FGF23 and bone strength in infants
por: Enlund-Cerullo, Maria, et al.
Publicado: (2023)

Development of a person-centred digital platform for the long-term support of people living with an adult-onset genetic disease predisposition: a mixed-methods study protocol
por: Best, Stephanie, et al.
Publicado: (2023)

High Impact Exercise Improves Bone Microstructure and Strength in Growing Rats
por: Mustafy, Tanvir, et al.
Publicado: (2019)

EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence
por: Gautheron, Jeremie, et al.
Publicado: (2021)

A human cancer-associated truncation of MBD4 causes dominant negative impairment of DNA repair in colon cancer cells
por: Bader, S A, et al.
Publicado: (2007)

Colonization of a commercial broiler line by Campylobacter is under limited genetic control and does not significantly impair performance or intestinal health
por: Bailey, Richard A, et al.
Publicado: (2018)

Identification of novel variants and candidate genes associated with porcine bone mineral density using genome-wide association study
por: Nan, Jiuhong-H, et al.
Publicado: (2020)

Comparison of bone microstructure and strength in the distal radius and tibia between the different types of primary hypertrophic osteoarthropathy: an HR-pQCT study
por: Pang, Qianqian, et al.
Publicado: (2023)

Impaired expression of protein phosphatase 2A subunits enhances metastatic potential of human prostate cancer cells through activation of AKT pathway
por: Pandey, P, et al.
Publicado: (2013)

The Effects of Osteoporotic and Non-osteoporotic Medications on Fracture Risk and Bone Mineral Density
por: van der Burgh, Anna C., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_uo28ckge51ob1t8r7i5vutafho