Ancestral protein reconstruction reveals evolutionary events governing variation in Dicer helicase function

Antiviral defense in ecdysozoan invertebrates requires Dicer with a helicase domain capable of ATP hydrolysis. But despite well-conserved ATPase motifs, human Dicer is incapable of ATP hydrolysis, consistent with a muted role in antiviral defense. To investigate this enigma, we used ancestral protei...

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Detalles Bibliográficos
Autores principales: Aderounmu, Adedeji M, Aruscavage, P Joseph, Kolaczkowski, Bryan, Bass, Brenda L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10159624/
https://www.ncbi.nlm.nih.gov/pubmed/37068011
http://dx.doi.org/10.7554/eLife.85120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10159624/
https://www.ncbi.nlm.nih.gov/pubmed/37068011
http://dx.doi.org/10.7554/eLife.85120

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