Contributions of replicative and translesion DNA polymerases to mutagenic bypass of canonical and atypical UV photoproducts

UV exposure induces a mutation signature of C > T substitutions at dipyrimidines in skin cancers. We recently identified additional UV-induced AC > TT and A > T substitutions that could respectively cause BRAF V600K and V600E oncogenic mutations. The mutagenic bypass mechanism past these at...

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Detalles Bibliográficos
Autores principales: Vandenberg, Brittany N., Laughery, Marian F., Cordero, Cameron, Plummer, Dalton, Mitchell, Debra, Kreyenhagen, Jordan, Albaqshi, Fatimah, Brown, Alexander J., Mieczkowski, Piotr A., Wyrick, John J., Roberts, Steven A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160025/
https://www.ncbi.nlm.nih.gov/pubmed/37142570
http://dx.doi.org/10.1038/s41467-023-38255-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160025/
https://www.ncbi.nlm.nih.gov/pubmed/37142570
http://dx.doi.org/10.1038/s41467-023-38255-5

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