Engineered repeat proteins as scaffolds to assemble multi-enzyme systems for efficient cell-free biosynthesis

Multi-enzymatic cascades with enzymes arranged in close-proximity through a protein scaffold can trigger a substrate channeling effect, allowing for efficient cofactor reuse with industrial potential. However, precise nanometric organization of enzymes challenges the design of scaffolds. In this stu...

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Detalles Bibliográficos
Autores principales: Ledesma-Fernandez, Alba, Velasco-Lozano, Susana, Santiago-Arcos, Javier, López-Gallego, Fernando, Cortajarena, Aitziber L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160029/
https://www.ncbi.nlm.nih.gov/pubmed/37142589
http://dx.doi.org/10.1038/s41467-023-38304-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160029/
https://www.ncbi.nlm.nih.gov/pubmed/37142589
http://dx.doi.org/10.1038/s41467-023-38304-z

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