Structure of dimeric lipoprotein lipase reveals a pore adjacent to the active site

Lipoprotein lipase (LPL) hydrolyzes triglycerides from circulating lipoproteins, releasing free fatty acids. Active LPL is needed to prevent hypertriglyceridemia, which is a risk factor for cardiovascular disease (CVD). Using cryogenic electron microscopy (cryoEM), we determined the structure of an...

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Detalles Bibliográficos
Autores principales: Gunn, Kathryn H., Neher, Saskia B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160067/
https://www.ncbi.nlm.nih.gov/pubmed/37142573
http://dx.doi.org/10.1038/s41467-023-38243-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160067/
https://www.ncbi.nlm.nih.gov/pubmed/37142573
http://dx.doi.org/10.1038/s41467-023-38243-9

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