C/EBPβ-LIP mediated activation of the malate-aspartate shuttle sensitizes cells to glycolysis inhibition

OBJECTIVE: Cancer cells use glycolysis for generation of metabolic intermediates and ATP needed for cell growth and proliferation. The transcription factor C/EBPβ-LIP stimulates glycolysis and mitochondrial respiration in cancer cells. We initially observed that high expression of C/EBPβ-LIP makes c...

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Detalles Bibliográficos
Autores principales: Ackermann, Tobias, Zuidhof, Hidde R., Müller, Christine, Kortman, Gertrud, Rutten, Martijn G.S., Broekhuis, Mathilde J.C., Zaini, Mohamad Amr, Hartleben, Götz, Calkhoven, Cornelis F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160650/
https://www.ncbi.nlm.nih.gov/pubmed/37062524
http://dx.doi.org/10.1016/j.molmet.2023.101726

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160650/
https://www.ncbi.nlm.nih.gov/pubmed/37062524
http://dx.doi.org/10.1016/j.molmet.2023.101726

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