Modeling group heteroscedasticity in single-cell RNA-seq pseudo-bulk data

Group heteroscedasticity is commonly observed in pseudo-bulk single-cell RNA-seq datasets and its presence can hamper the detection of differentially expressed genes. Since most bulk RNA-seq methods assume equal group variances, we introduce two new approaches that account for heteroscedastic groups...

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Detalles Bibliográficos
Autores principales: You, Yue, Dong, Xueyi, Wee, Yong Kiat, Maxwell, Mhairi J., Alhamdoosh, Monther, Smyth, Gordon K., Hickey, Peter F., Ritchie, Matthew E., Law, Charity W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160736/
https://www.ncbi.nlm.nih.gov/pubmed/37147723
http://dx.doi.org/10.1186/s13059-023-02949-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160736/
https://www.ncbi.nlm.nih.gov/pubmed/37147723
http://dx.doi.org/10.1186/s13059-023-02949-2

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