Allosteric communication between ligand binding domains modulates substrate inhibition in adenylate kinase

Enzymes play a vital role in life processes; they control chemical reactions and allow functional cycles to be synchronized. Many enzymes harness large-scale motions of their domains to achieve tremendous catalytic prowess and high selectivity for specific substrates. One outstanding example is prov...

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Detalles Bibliográficos
Autores principales: Scheerer, David, Adkar, Bharat V., Bhattacharyya, Sanchari, Levy, Dorit, Iljina, Marija, Riven, Inbal, Dym, Orly, Haran, Gilad, Shakhnovich, Eugene I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Physical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160949/
https://www.ncbi.nlm.nih.gov/pubmed/37094144
http://dx.doi.org/10.1073/pnas.2219855120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160949/
https://www.ncbi.nlm.nih.gov/pubmed/37094144
http://dx.doi.org/10.1073/pnas.2219855120

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