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Allosteric communication between ligand binding domains modulates substrate inhibition in adenylate kinase
Enzymes play a vital role in life processes; they control chemical reactions and allow functional cycles to be synchronized. Many enzymes harness large-scale motions of their domains to achieve tremendous catalytic prowess and high selectivity for specific substrates. One outstanding example is prov...
Autores principales: | Scheerer, David, Adkar, Bharat V., Bhattacharyya, Sanchari, Levy, Dorit, Iljina, Marija, Riven, Inbal, Dym, Orly, Haran, Gilad, Shakhnovich, Eugene I. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160949/ https://www.ncbi.nlm.nih.gov/pubmed/37094144 http://dx.doi.org/10.1073/pnas.2219855120 |
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