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Marginal specificity in protein interactions constrains evolution of a paralogous family

The evolution of novel functions in biology relies heavily on gene duplication and divergence, creating large paralogous protein families. Selective pressure to avoid detrimental cross-talk often results in paralogs that exhibit exquisite specificity for their interaction partners. But how robust or...

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Detalles Bibliográficos
Autores principales: Ghose, Dia A., Przydzial, Kaitlyn E., Mahoney, Emily M., Keating, Amy E., Laub, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160972/
https://www.ncbi.nlm.nih.gov/pubmed/37098061
http://dx.doi.org/10.1073/pnas.2221163120