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Structural insights into HIV-1 polyanion-dependent capsid lattice formation revealed by single particle cryo-EM

The HIV-1 capsid houses the viral genome and interacts extensively with host cell proteins throughout the viral life cycle. It is composed of capsid protein (CA), which assembles into a conical fullerene lattice composed of roughly 200 CA hexamers and 12 CA pentamers. Previous structural analyses of...

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Detalles Bibliográficos
Autores principales: Highland, Carolyn M., Tan, Aaron, Ricaña, Clifton L., Briggs, John A. G., Dick, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160977/
https://www.ncbi.nlm.nih.gov/pubmed/37094124
http://dx.doi.org/10.1073/pnas.2220545120