Small-molecule targeting of GPCR-independent noncanonical G-protein signaling in cancer

Activation of heterotrimeric G-proteins (Gαβγ) by G-protein-coupled receptors (GPCRs) is a quintessential mechanism of cell signaling widely targeted by clinically approved drugs. However, it has become evident that heterotrimeric G-proteins can also be activated via GPCR-independent mechanisms that...

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Detalles Bibliográficos
Autores principales: Zhao, Jingyi, DiGiacomo, Vincent, Ferreras-Gutierrez, Mariola, Dastjerdi, Shiva, Ibáñez de Opakua, Alain, Park, Jong-Chan, Luebbers, Alex, Chen, Qingyan, Beeler, Aaron, Blanco, Francisco J., Garcia-Marcos, Mikel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160980/
https://www.ncbi.nlm.nih.gov/pubmed/37098067
http://dx.doi.org/10.1073/pnas.2213140120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160980/
https://www.ncbi.nlm.nih.gov/pubmed/37098067
http://dx.doi.org/10.1073/pnas.2213140120

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