Ago2 and a miRNA reduce Topoisomerase 1 for enhancing DNA cleavage in antibody diversification by activation-induced cytidine deaminase

Activation-induced cytidine deaminase (AID) is the essential enzyme for imprinting immunological memory through class switch recombination (CSR) and somatic hypermutation (SHM) of the immunoglobulin (Ig) gene. AID-dependent reduction of Topoisomerase 1 (Top1) promotes DNA cleavage that occurs upon I...

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Detalles Bibliográficos
Autores principales: Kobayashi, Maki, Wakaguri, Hiroyuki, Shimizu, Masakazu, Higasa, Koichiro, Matsuda, Fumihiko, Honjo, Tasuku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161001/
https://www.ncbi.nlm.nih.gov/pubmed/37094168
http://dx.doi.org/10.1073/pnas.2216918120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161001/
https://www.ncbi.nlm.nih.gov/pubmed/37094168
http://dx.doi.org/10.1073/pnas.2216918120

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