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Ago2 and a miRNA reduce Topoisomerase 1 for enhancing DNA cleavage in antibody diversification by activation-induced cytidine deaminase

Activation-induced cytidine deaminase (AID) is the essential enzyme for imprinting immunological memory through class switch recombination (CSR) and somatic hypermutation (SHM) of the immunoglobulin (Ig) gene. AID-dependent reduction of Topoisomerase 1 (Top1) promotes DNA cleavage that occurs upon I...

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Detalles Bibliográficos
Autores principales:	Kobayashi, Maki, Wakaguri, Hiroyuki, Shimizu, Masakazu, Higasa, Koichiro, Matsuda, Fumihiko, Honjo, Tasuku
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2023
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161001/ https://www.ncbi.nlm.nih.gov/pubmed/37094168 http://dx.doi.org/10.1073/pnas.2216918120

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