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Exploiting conformational dynamics to modulate the function of designed proteins

With the recent success in calculating protein structures from amino acid sequences using artificial intelligence-based algorithms, an important next step is to decipher how dynamics is encoded by the primary protein sequence so as to better predict function. Such dynamics information is critical fo...

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Detalles Bibliográficos
Autores principales: Rennella, Enrico, Sahtoe, Danny D., Baker, David, Kay, Lewis E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161014/
https://www.ncbi.nlm.nih.gov/pubmed/37094170
http://dx.doi.org/10.1073/pnas.2303149120