Polydopamine Nanoparticles Targeting Ferroptosis Mitigate Intervertebral Disc Degeneration Via Reactive Oxygen Species Depletion, Iron Ions Chelation, and GPX4 Ubiquitination Suppression

Intervertebral disc degeneration (IVDD)‐induced lower back pain (LBP) is a common problem worldwide. The underlying mechanism is partially accredited to ferroptosis, based on sequencing analyses of IVDD patients from the gene expression omnibus (GEO) databases. In this study, it is shown that polydo...

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Detalles Bibliográficos
Autores principales: Yang, Xiao, Chen, Yan, Guo, Jiadong, Li, Jiaxin, Zhang, Pu, Yang, Huan, Rong, Kewei, Zhou, Tangjun, Fu, Jingke, Zhao, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161035/
https://www.ncbi.nlm.nih.gov/pubmed/36951540
http://dx.doi.org/10.1002/advs.202207216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161035/
https://www.ncbi.nlm.nih.gov/pubmed/36951540
http://dx.doi.org/10.1002/advs.202207216

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