Synthetic Ionizable Colloidal Drug Aggregates Enable Endosomal Disruption

Colloidal drug aggregates enable the design of drug‐rich nanoparticles; however, the efficacy of stabilized colloidal drug aggregates is limited by entrapment in the endo‐lysosomal pathway. Although ionizable drugs are used to elicit lysosomal escape, this approach is hindered by toxicity associated...

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Detalles Bibliográficos
Autores principales: Donders, Eric N., Slaughter, Kai V., Dank, Christian, Ganesh, Ahil N., Shoichet, Brian K., Lautens, Mark, Shoichet, Molly S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161099/
https://www.ncbi.nlm.nih.gov/pubmed/36905240
http://dx.doi.org/10.1002/advs.202300311

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161099/
https://www.ncbi.nlm.nih.gov/pubmed/36905240
http://dx.doi.org/10.1002/advs.202300311

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