Determining the Location of the α-Synuclein Dimer Interface Using Native Top-Down Fragmentation and Isotope Depletion-Mass Spectrometry

[Image: see text] α-Synuclein (αSyn), a 140-residue intrinsically disordered protein, comprises the primary proteinaceous component of pathology-associated Lewy body inclusions in Parkinson’s disease (PD). Due to its association with PD, αSyn is studied extensively; however, the endogenous structure...

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Detalles Bibliográficos
Autores principales: Jeacock, Kiani, Chappard, Alexandre, Gallagher, Kelly J., Mackay, C. Logan, Kilgour, David P. A., Horrocks, Mathew H., Kunath, Tilo, Clarke, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161212/
https://www.ncbi.nlm.nih.gov/pubmed/36976861
http://dx.doi.org/10.1021/jasms.2c00339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161212/
https://www.ncbi.nlm.nih.gov/pubmed/36976861
http://dx.doi.org/10.1021/jasms.2c00339

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