A strategy for high antibody expression with low anti-drug antibodies using AAV9 vectors

INTRODUCTION: Use of adeno-associated virus (AAV) vectors is complicated by host immune responses that can limit transgene expression. Recent clinical trials using AAV vectors to deliver HIV broadly neutralizing antibodies (bNAbs) by intramuscular administration resulted in poor expression with anti...

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Detalles Bibliográficos
Autores principales: Davis-Gardner, Meredith E., Weber, Jesse A., Xie, Jun, Pekrun, Katja, Alexander, Eric A., Weisgrau, Kim L., Furlott, Jessica R., Rakasz, Eva G., Kay, Mark A., Gao, Guangping, Farzan, Michael, Gardner, Matthew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161250/
https://www.ncbi.nlm.nih.gov/pubmed/37153616
http://dx.doi.org/10.3389/fimmu.2023.1105617

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161250/
https://www.ncbi.nlm.nih.gov/pubmed/37153616
http://dx.doi.org/10.3389/fimmu.2023.1105617

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