Down syndrome: insights into autoimmune mechanisms

Understanding why individuals with Down syndrome are highly predisposed to autoimmunity has broad mechanistic and therapeutic implications. New work identifies novel potential mechanistic pathways driving increased autoimmunity-relevant CD11c(+) B cells and provides the broadest view to date of the...

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Detalles Bibliográficos
Autores principales: Khor, Bernard, Buckner, Jane H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
News & Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161987/
https://www.ncbi.nlm.nih.gov/pubmed/37147460
http://dx.doi.org/10.1038/s41584-023-00970-0
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author Khor, Bernard
Buckner, Jane H.
author_facet Khor, Bernard
Buckner, Jane H.
author_sort Khor, Bernard
collection PubMed
description Understanding why individuals with Down syndrome are highly predisposed to autoimmunity has broad mechanistic and therapeutic implications. New work identifies novel potential mechanistic pathways driving increased autoimmunity-relevant CD11c(+) B cells and provides the broadest view to date of the repertoire of autoantibodies generated in individuals with Down syndrome.
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spelling pubmed-101619872023-05-09 Down syndrome: insights into autoimmune mechanisms Khor, Bernard Buckner, Jane H. Nat Rev Rheumatol News & Views Understanding why individuals with Down syndrome are highly predisposed to autoimmunity has broad mechanistic and therapeutic implications. New work identifies novel potential mechanistic pathways driving increased autoimmunity-relevant CD11c(+) B cells and provides the broadest view to date of the repertoire of autoantibodies generated in individuals with Down syndrome. Nature Publishing Group UK 2023-05-05 /pmc/articles/PMC10161987/ /pubmed/37147460 http://dx.doi.org/10.1038/s41584-023-00970-0 Text en © Springer Nature Limited 2023 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle News & Views
Khor, Bernard
Buckner, Jane H.
Down syndrome: insights into autoimmune mechanisms
title Down syndrome: insights into autoimmune mechanisms
title_full Down syndrome: insights into autoimmune mechanisms
title_fullStr Down syndrome: insights into autoimmune mechanisms
title_full_unstemmed Down syndrome: insights into autoimmune mechanisms
title_short Down syndrome: insights into autoimmune mechanisms
title_sort down syndrome: insights into autoimmune mechanisms
topic News & Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161987/
https://www.ncbi.nlm.nih.gov/pubmed/37147460
http://dx.doi.org/10.1038/s41584-023-00970-0
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