p35 is a Crucial Player in NK-cell Cytotoxicity and TGFβ-mediated NK-cell Dysfunction

Natural killer (NK) cells are innate lymphocytes with cytotoxic activity. Understanding the factors regulating cytotoxicity is crucial for improving NK-cell adoptive therapies. Here, we studied a previously unknown role of p35 (CDK5R1), a coactivator of cyclin-dependent kinase 5 (CDK5) in NK-cell fu...

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Detalles Bibliográficos
Autores principales: Wong, Derek P., Fritz, Claire E., Feinberg, Daniel, Huang, Alex Y., Parameswaran, Reshmi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10162136/
https://www.ncbi.nlm.nih.gov/pubmed/37377891
http://dx.doi.org/10.1158/2767-9764.CRC-22-0497

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10162136/
https://www.ncbi.nlm.nih.gov/pubmed/37377891
http://dx.doi.org/10.1158/2767-9764.CRC-22-0497

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