Delivery of a novel membrane-anchored Fc chimera enhances NK cell-mediated killing of tumor cells and persistently virus-infected cells

Antibody-dependent cellular cytotoxicity (ADCC) is one of the most powerful mechanisms for Natural Killer (NK) cells to kill cancer cells or virus-infected cells. A novel chimeric protein (NA-Fc) was created, which when expressed in cells, positions an IgG Fc domain on the plasma membrane, mimicking...

Descripción completa

Detalles Bibliográficos
Autores principales: Varudkar, Namita, Shiffer, Elisabeth M., Oyer, Jeremiah L., Copik, Alicja, Parks, Griffith D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10162523/
https://www.ncbi.nlm.nih.gov/pubmed/37146009
http://dx.doi.org/10.1371/journal.pone.0285532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10162523/
https://www.ncbi.nlm.nih.gov/pubmed/37146009
http://dx.doi.org/10.1371/journal.pone.0285532

Ejemplares similares