Shear and hydrostatic stress regulate fetal heart valve remodeling through YAP-mediated mechanotransduction

Clinically serious congenital heart valve defects arise from improper growth and remodeling of endocardial cushions into leaflets. Genetic mutations have been extensively studied but explain less than 20% of cases. Mechanical forces generated by beating hearts drive valve development, but how these...

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Detalles Bibliográficos
Autores principales: Wang, Mingkun, Lin, Belle Yanyu, Sun, Shuofei, Dai, Charles, Long, Feifei, Butcher, Jonathan T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10162797/
https://www.ncbi.nlm.nih.gov/pubmed/37078699
http://dx.doi.org/10.7554/eLife.83209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10162797/
https://www.ncbi.nlm.nih.gov/pubmed/37078699
http://dx.doi.org/10.7554/eLife.83209

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