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Shear and hydrostatic stress regulate fetal heart valve remodeling through YAP-mediated mechanotransduction
Clinically serious congenital heart valve defects arise from improper growth and remodeling of endocardial cushions into leaflets. Genetic mutations have been extensively studied but explain less than 20% of cases. Mechanical forces generated by beating hearts drive valve development, but how these...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10162797/ https://www.ncbi.nlm.nih.gov/pubmed/37078699 http://dx.doi.org/10.7554/eLife.83209 |