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Pancreatic β-cell glutaminase 2 maintains glucose homeostasis under the condition of hyperglycaemia
Glutaminase 2 (GLS2), a master regulator of glutaminolysis that is induced by p53 and converts glutamine to glutamate, is abundant in the liver but also exists in pancreatic β-cells. However, the roles of GLS2 in islets associated with glucose metabolism are unknown, presenting a critical issue. To...
Autores principales: | Deguchi-Horiuchi, Hanna, Suzuki, Sawako, Lee, Eun Young, Miki, Takashi, Yamanaka, Noriko, Manabe, Ichiro, Tanaka, Tomoaki, Yokote, Koutaro |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10162969/ https://www.ncbi.nlm.nih.gov/pubmed/37147373 http://dx.doi.org/10.1038/s41598-023-34336-z |
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