The antifungal effect induced by itraconazole in Candida parapsilosis largely depends on the oxidative stress generated at the mitochondria

In Candida parapsilosis, homozygous disruption of the two genes encoding trehalase activity increased the susceptibility to Itraconazole compared with the isogenic parental strain. The fungicidal effect of this azole can largely be counteracted by preincubating growing cells with rotenone and the pr...

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Detalles Bibliográficos
Autores principales: Muñoz-Megías, Mª Luz, Sánchez-Fresneda, Ruth, Solano, Francisco, Maicas, Sergi, Martínez-Esparza, María, Argüelles, Juan-Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163099/
https://www.ncbi.nlm.nih.gov/pubmed/37119267
http://dx.doi.org/10.1007/s00294-023-01269-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163099/
https://www.ncbi.nlm.nih.gov/pubmed/37119267
http://dx.doi.org/10.1007/s00294-023-01269-z

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