Implementation of dihydropyrimidine dehydrogenase deficiency testing in Europe

BACKGROUND: The main cause for fluoropyrimidine-related toxicity is deficiency of the metabolizing enzyme dihydropyrimidine dehydrogenase (DPD). In 2020, the European Medicines Agency (EMA) recommended two methods for pre-treatment DPD deficiency testing in clinical practice: phenotyping using endog...

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Detalles Bibliográficos
Autores principales: de With, M., Sadlon, A., Cecchin, E., Haufroid, V., Thomas, F., Joerger, M., van Schaik, R.H.N., Mathijssen, R.H.J., Largiadèr, C.R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163157/
https://www.ncbi.nlm.nih.gov/pubmed/36989883
http://dx.doi.org/10.1016/j.esmoop.2023.101197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163157/
https://www.ncbi.nlm.nih.gov/pubmed/36989883
http://dx.doi.org/10.1016/j.esmoop.2023.101197

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