Distinct activation mechanisms regulate subtype selectivity of Cannabinoid receptors

Design of cannabinergic subtype selective ligands is challenging because of high sequence and structural similarities of cannabinoid receptors (CB(1) and CB(2)). We hypothesize that the subtype selectivity of designed selective ligands can be explained by the ligand binding to the conformationally d...

Descripción completa

Detalles Bibliográficos
Autores principales: Dutta, Soumajit, Shukla, Diwakar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163236/
https://www.ncbi.nlm.nih.gov/pubmed/37147497
http://dx.doi.org/10.1038/s42003-023-04868-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163236/
https://www.ncbi.nlm.nih.gov/pubmed/37147497
http://dx.doi.org/10.1038/s42003-023-04868-1

Ejemplares similares