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Distinct activation mechanisms regulate subtype selectivity of Cannabinoid receptors
Design of cannabinergic subtype selective ligands is challenging because of high sequence and structural similarities of cannabinoid receptors (CB(1) and CB(2)). We hypothesize that the subtype selectivity of designed selective ligands can be explained by the ligand binding to the conformationally d...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163236/ https://www.ncbi.nlm.nih.gov/pubmed/37147497 http://dx.doi.org/10.1038/s42003-023-04868-1 |