Improving de novo protein binder design with deep learning

Recently it has become possible to de novo design high affinity protein binding proteins from target structural information alone. There is, however, considerable room for improvement as the overall design success rate is low. Here, we explore the augmentation of energy-based protein binder design u...

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Detalles Bibliográficos
Autores principales: Bennett, Nathaniel R., Coventry, Brian, Goreshnik, Inna, Huang, Buwei, Allen, Aza, Vafeados, Dionne, Peng, Ying Po, Dauparas, Justas, Baek, Minkyung, Stewart, Lance, DiMaio, Frank, De Munck, Steven, Savvides, Savvas N., Baker, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163288/
https://www.ncbi.nlm.nih.gov/pubmed/37149653
http://dx.doi.org/10.1038/s41467-023-38328-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163288/
https://www.ncbi.nlm.nih.gov/pubmed/37149653
http://dx.doi.org/10.1038/s41467-023-38328-5

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