Neuronal overexpression of hTDP-43 in Caenorhabditis elegans mimics the cellular pathology commonly observed in TDP-43 proteinopathies

Inclusions consisting of transactive response DNA-binding protein 43 (TDP-43) are a characteristic feature of amyotrophic lateral sclerosis (ALS). Caenorhabditis elegans has been instrumental in studying the underlying mechanisms of TDP-43 pathology. Here, we extend the possibilities of previous stu...

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Detalles Bibliográficos
Autores principales: Koopman, Mandy, Güngördü, Lale, Seinstra, Renée I., Hogewerf, Wytse, Nollen, Ellen A. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2023
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163326/
https://www.ncbi.nlm.nih.gov/pubmed/37159575
http://dx.doi.org/10.17912/micropub.biology.000767

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163326/
https://www.ncbi.nlm.nih.gov/pubmed/37159575
http://dx.doi.org/10.17912/micropub.biology.000767

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