Metformin improves cancer immunotherapy by directly rescuing tumor-infiltrating CD8 T lymphocytes from hypoxia-induced immunosuppression

BACKGROUND: Despite their revolutionary success in cancer treatment over the last decades, immunotherapies encounter limitations in certain tumor types and patients. The efficacy of immunotherapies depends on tumor antigen-specific CD8 T-cell viability and functionality within the immunosuppressive...

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Detalles Bibliográficos
Autores principales: Finisguerra, Veronica, Dvorakova, Tereza, Formenti, Matteo, Van Meerbeeck, Pierre, Mignion, Lionel, Gallez, Bernard, Van den Eynde, Benoit J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163559/
https://www.ncbi.nlm.nih.gov/pubmed/37147018
http://dx.doi.org/10.1136/jitc-2022-005719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163559/
https://www.ncbi.nlm.nih.gov/pubmed/37147018
http://dx.doi.org/10.1136/jitc-2022-005719

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