E3 ubiquitin ligase RNF180 prevents excessive PCDH10 methylation to suppress the proliferation and metastasis of gastric cancer cells by promoting ubiquitination of DNMT1

BACKGROUND: Downregulation of certain tumor-suppressor genes (TSGs) by aberrant methylation of CpG islands in the promoter region contributes a great deal to the oncogenesis and progression of several cancers, including gastric cancer (GC). Protocadherin 10 (PCDH10) is a newly identified TSG in vari...

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Detalles Bibliográficos
Autores principales: Zhang, Nannan, Gao, Xiaoliang, Yuan, Qiangqiang, Fu, Xin, Wang, Pengliang, Cai, Fenglin, Liu, Hui, Zhang, Jing, Liang, Han, Nie, Yongzhan, Deng, Jingyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163782/
https://www.ncbi.nlm.nih.gov/pubmed/37147733
http://dx.doi.org/10.1186/s13148-023-01492-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163782/
https://www.ncbi.nlm.nih.gov/pubmed/37147733
http://dx.doi.org/10.1186/s13148-023-01492-y

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