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BK channel modulation by positively charged peptides and auxiliary γ subunits mediated by the Ca(2+)-bowl site

The large-conductance, Ca(2+)-, and voltage-activated K(+) (BK) channel consists of the pore-forming α (BKα) subunit and regulatory β and γ subunits. The γ1–3 subunits facilitate BK channel activation by shifting the voltage-dependence of channel activation toward the hyperpolarization direction by...

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Detalles Bibliográficos
Autores principales: Chen, Guanxing, Li, Qin, Webb, Timothy I., Hollywood, Mark A., Yan, Jiusheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163825/
https://www.ncbi.nlm.nih.gov/pubmed/37130264
http://dx.doi.org/10.1085/jgp.202213237